Timing of high-intensity pulses for myocardial cavitation-enabled therapy

Timing of high-intensity pulses for myocardial cavitation-enabled therapy

BACKGROUND High-intensity ultrasound pulses intermittently triggered from an ECG signal can interact with circulating contrast agent microbubbles to produce myocardial cavitation microlesions of potential therapeutic value. In this study, the timing of therapy pulses relative to the ECG R wave was investigated to identify the optimal time point for tissue reduction therapy with regard to both t...

Multiple ultrasound cavitation-enabled treatments for myocardial reduction

Background Ultrasound myocardial cavitation enabled treatment (MCET) is an image-guided method for tissue reduction. In this study, a strategy of fractionated (multiple) treatments was tested for efficacy. Methods Dahl SS rats were anesthetized and prepared for treatment with a focused ultrasound transducer in a warm water bath. Aiming at the anterior left ventricular wall was facilitated by ...

Gold nanoparticle nucleated cavitation for enhanced high intensity focused ultrasound therapy.

High intensity focused ultrasound (HIFU) or focused ultrasound surgery is a non-invasive technique for the treatment of cancerous tissue, which is limited by difficulties in getting real-time feedback on treatment progress and long treatment durations. The formation and activity of acoustic cavitation, specifically inertial cavitation, during HIFU exposures has been demonstrated to enhance heat...

Pressure Pulses Generated by Cloud Cavitation

This paper describes an experimental investigation of the large unsteady and impulsive pressures which are experienced on the suction surface of both an oscillating and static hydrofoil as a result of cloud cavitation. The present experiments used piezo-electric transducers t o measure unsteady pressures at four locations along the chord of the foil and a t two locations along the walls of the ...

Optimizing Ultrasonic Intensity for High Intensity Focused Ultrasound Therapy